Febuxostat and Lufyllin-400

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using febuxostat together with dyphylline. Combining these medications may alter the way that dyphylline is broken down in the body and lead to increased blood levels of a byproduct of dyphylline. Currently, the potential effects (if any) of having increased levels of the byproduct are unknown. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with febuxostat may alter the pharmacokinetics of theophylline. The proposed mechanism is inhibition of xanthine oxidase by febuxostat. In healthy volunteers, administration of theophylline in combination with febuxostat 80 mg once daily resulted in a 6% increase in theophylline peak plasma concentration (Cmax) and a 6.5% increase in systemic exposure (AUC). These changes were not considered statistically or clinically significant. However, the study also showed an approximately 400-fold increase in the urinary excretion of 1-methylxanthine, one of the major theophylline metabolites. The safety of long-term exposure to 1-methylxanthine has not been evaluated.

MANAGEMENT: No dosage adjustment is necessary for theophylline when coadministered with febuxostat, but caution is advised. Because the safety of long-term exposure to 1-methylxanthine is unknown, this should be taken into consideration when deciding to use the combination.

Febuxostat

Generic Name: febuxostat

Brand name: Uloric

Synonyms: n.a.

What is Febuxostat?

Lufyllin-400

Generic Name: dyphylline

Brand name:

Synonyms: n.a.

What is Lufyllin-400?