Febuxostat and Ritonavir
Determining the interaction of Febuxostat and Ritonavir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Potent inducers of UGT enzymes (e.g., rifampin, carbamazepine, phenobarbital, phenytoin, ritonavir) may increase the metabolism of febuxostat and decrease its therapeutic efficacy. Febuxostat undergoes extensive metabolism by both conjugation via UGT enzymes including UGT1A1, UGT1A3, UGT1A9, and UGT2B7, and oxidation via cytochrome P450 enzymes. The relative contribution of each isoenzyme and the clinical significance is unknown. Conversely, increased plasma levels of febuxostat may occur after a potent UGT inducer is discontinued.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: ritonavir
Brand name: Norvir, Norvir Soft Gelatin
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Febuxostat-Ritonavir Capsules
- Febuxostat-Ritonavir Oral Solution
- Febuxostat-Ritonavir Powder Packets
- Febuxostat-Ritonavir Tablets
- Febuxostat-Rituxan
- Febuxostat-Rituxan Hycela
- Ritonavir-Febuxostat Tablets
- Ritonavir-Fedratinib
- Ritonavir-Fedratinib Hydrochloride
- Ritonavir-Feiba
- Ritonavir-Feiba NF
- Ritonavir-Feiba VH Immuno