Fedratinib and Nexium (Esomeprazole Powder for Suspension)
Determining the interaction of Fedratinib and Nexium (Esomeprazole Powder for Suspension) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with CYP450 2C19 inhibitors may increase the plasma concentrations of fedratinib, which is a substrate of the isoenzyme. However, clinical data evaluating the interaction are not available. MANAGEMENT: Caution is recommended with the concomitant use of fedratinib and CYP450 2C19 inhibitors. Patients should be monitored for adverse effects including anemia, thrombocytopenia, diarrhea, nausea, vomiting, and liver (ALT, AST) and pancreatic (amylase, lipase) enzyme elevations. References "Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.
Professional:MONITOR: Coadministration with CYP450 2C19 inhibitors may increase the plasma concentrations of fedratinib, which is a substrate of the isoenzyme. However, clinical data evaluating the interaction are not available.
MANAGEMENT: Caution is recommended with the concomitant use of fedratinib and CYP450 2C19 inhibitors. Patients should be monitored for adverse effects including anemia, thrombocytopenia, diarrhea, nausea, vomiting, and liver (ALT, AST) and pancreatic (amylase, lipase) enzyme elevations.
- "Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.
Generic Name: esomeprazole
Brand name: Nexium, Esomeprazole Strontium, Nexium, NexIUM 24HR, Nexium IV
Synonyms: Nexium
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fedratinib-Nexium 24HR (Esomeprazole Delayed-Release Capsules)
- Fedratinib-NexIUM 24HR (Esomeprazole Delayed-Release Tablets)
- Fedratinib-Nexium Capsules
- Fedratinib-Nexium I.V.
- Fedratinib-Nexium I.V. Injection
- Fedratinib-Nexium Oral
- Nexium (Esomeprazole Powder for Suspension)-Fedratinib Hydrochloride
- Nexium (Esomeprazole Powder for Suspension)-Feiba
- Nexium (Esomeprazole Powder for Suspension)-Feiba NF
- Nexium (Esomeprazole Powder for Suspension)-Feiba VH Immuno
- Nexium (Esomeprazole Powder for Suspension)-Feiba-VH
- Nexium (Esomeprazole Powder for Suspension)-Felbamate