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Fedratinib Hydrochloride and Fluconazole in Dextrose Injection

Determining the interaction of Fedratinib Hydrochloride and Fluconazole in Dextrose Injection and the possibility of their joint administration.

Check result:
Fedratinib Hydrochloride <> Fluconazole in Dextrose Injection
Relevance: 24.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with dual CYP450 3A4 and 2C19 inhibitors may increase the plasma concentrations of fedratinib, which is a substrate of these isoenzymes. However, clinical data evaluating the interaction are not available. MANAGEMENT: According to the product labeling, concomitant use of fedratinib with dual CYP450 3A4 and 2C19 inhibitors should be avoided. References "Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.

Professional:

GENERALLY AVOID: Coadministration with dual CYP450 3A4 and 2C19 inhibitors may increase the plasma concentrations of fedratinib, which is a substrate of these isoenzymes. However, clinical data evaluating the interaction are not available.

MANAGEMENT: According to the product labeling, concomitant use of fedratinib with dual CYP450 3A4 and 2C19 inhibitors should be avoided.

References
  • "Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.
Fedratinib Hydrochloride

Generic Name: fedratinib

Brand name: Inrebic

Synonyms: Fedratinib

Fluconazole in Dextrose Injection

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Fluconazole

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.