Fedratinib Hydrochloride and Lansoprazole Orally Disintegrating Tablets
Determining the interaction of Fedratinib Hydrochloride and Lansoprazole Orally Disintegrating Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with CYP450 2C19 inhibitors may increase the plasma concentrations of fedratinib, which is a substrate of the isoenzyme. However, clinical data evaluating the interaction are not available. MANAGEMENT: Caution is recommended with the concomitant use of fedratinib and CYP450 2C19 inhibitors. Patients should be monitored for adverse effects including anemia, thrombocytopenia, diarrhea, nausea, vomiting, and liver (ALT, AST) and pancreatic (amylase, lipase) enzyme elevations. References "Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.
Professional:MONITOR: Coadministration with CYP450 2C19 inhibitors may increase the plasma concentrations of fedratinib, which is a substrate of the isoenzyme. However, clinical data evaluating the interaction are not available.
MANAGEMENT: Caution is recommended with the concomitant use of fedratinib and CYP450 2C19 inhibitors. Patients should be monitored for adverse effects including anemia, thrombocytopenia, diarrhea, nausea, vomiting, and liver (ALT, AST) and pancreatic (amylase, lipase) enzyme elevations.
- "Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.
Generic Name: fedratinib
Brand name: Inrebic
Synonyms: Fedratinib
Generic Name: lansoprazole
Brand name: FIRST Lansoprazole, Prevacid, Prevacid OTC, Prevacid SoluTab
Synonyms: Lansoprazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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