Fedratinib Hydrochloride and Mekinist

• Generic Name: fedratinib
• Dosage Forms: n.a.
• Other Brand Names: Inrebic

Fedratinib hydrochloride is a kinase inhibitor indicated for the treatment of adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis (MF).

• Generic Name: trametinib
• Dosage Forms: tablet, film coated
• Other Brand Names: Mekinist

Mekinist (trametinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Mekinist is used alone or in combination with another medicine called dabrafenib (Tafinlar) to treat certain types of cancer in people who have a "BRAF" gene mutation.

Mekinist is for use in treating:

• melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body, or to prevent melanoma from coming back after surgery;

• non-small cell lung cancer that has spread to other parts of the body; or

• advanced or metastatic thyroid cancer that has spread and for which there are no other treatment options.