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Felbamate Tablets and Horizant

Determining the interaction of Felbamate Tablets and Horizant and the possibility of their joint administration.

Check result:
Felbamate Tablets <> Horizant
Relevance: 07.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

A retrospective study noted that the combined administration of felbamate and gabapentin may lead to a reduction in clearance and an increase in the half-life of felbamate. The mechanism may be due to a competition for renal excretion sites. The clinical significance is unknown. The clinician may want to more closely observe the patient for altered felbamate effects when gabapentin is started or stopped. The dose of felbamate may need to be adjusted if an interaction is suspected.

References
  • Hussein G, Troupin AS, Montouris G "Gabapentin interaction with felbamate." Neurology 47 (1996): 1106
Felbamate Tablets

Generic Name: felbamate

Brand name: Felbatol

Synonyms: Felbamate

Horizant

Generic Name: gabapentin enacarbil

Brand name: Horizant

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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