Felbatol (Felbamate Tablets) and Rifadin IV

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

RifAMPin may decrease the blood levels of felbamate. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with potent CYP450 3A4 inducers may decrease the plasma concentrations of felbamate, which may be a substrate of the isoenzyme. Pharmacokinetic data may not be available for all potent inducers with respect to their effect on felbamate. However, the potent CYP450 3A4 inducers carbamazepine, phenobarbital, and phenytoin have all been shown to decrease felbamate plasma concentrations. Felbamate steady-state trough concentrations have decreased by approximately 40% and 45% when administered with carbamazepine and phenytoin, respectively, compared to the same dose of felbamate monotherapy. In addition, concomitant use of phenobarbital resulted in a 29% decrease in felbamate steady-state plasma concentrations as compared to felbamate monotherapy.

MANAGEMENT: Caution is advised if felbamate is used concomitantly with potent CYP450 3A4 inducers. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever a potent CYP450 3A4 inducer is added to or withdrawn from therapy with felbamate.

Felbatol (Felbamate Tablets)

Generic Name: felbamate

Brand name: Felbatol

Synonyms: Felbatol

What is Felbatol (Felbamate Tablets)?

Rifadin IV

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: n.a.

What is Rifadin IV?