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Felodipine and Seconal Sodium

Determining the interaction of Felodipine and Seconal Sodium and the possibility of their joint administration.

Check result:

Felodipine <> Seconal Sodium

Relevance: 26.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking secobarbital, tell your doctor if you also use felodipine. You may need dose adjustments or special tests in order to safely take both medications together. This combination may decrease felodipine levels in your body. Blood pressure should be checked regularly. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Decreased felodipine bioavailability and serum levels have been reported in one study of 10 epileptic patients taking phenobarbital, phenytoin, and carbamazepine alone or in combination. AUC was reduced by 93%. The mechanism may be CYP450 enzyme induction by the anticonvulsants. Loss of antihypertensive efficacy may occur.

MANAGEMENT: Blood pressure should be monitored during concurrent administration. Dosage adjustments may be necessary. Alternative antihypertensives (e.g., amlodipine) may be considered.

References

Bahls FH, Ozuna J, Ritchie DE "Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin." Neurology 41 (1991): 740-2
Price WA, DiMarzio LR "Verapamil-carbamazepine neurotoxicity." J Clin Psychiatry 49 (1988): 80
Capewell S, Critchley JA, Freestone S, Pottage A, Prescott LF "Reduced felodipine bioavailability in patients taking anticonvulsants." Lancet 2 (1988): 480
Eimer M, Carter BL "Elevated serum carbamazepine concentrations following diltiazem initiation." Drug Intell Clin Pharm 21 (1987): 340-2
Beattie B, Biller J, Mehlhaus B, Murray M "Verapamil-induced carbamazepine neurotoxicity." Eur Neurol 28 (1988): 104-5
Capewell S, Critchley JA, Freestone S, et al "Reduced felodipine bioavailability in patients taking anticonvulsants." Lancet Aug (1988): 480-2

Felodipine

Generic Name: felodipine

Brand name: Plendil

Synonyms: n.a.

What is Felodipine?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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