Fenoldopam and GNP Day Time D Cold/Flu
Determining the interaction of Fenoldopam and GNP Day Time D Cold/Flu and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The use of acetaminophen has been associated with a 32% increase in orally-administered fenoldopam plasma concentrations and a 50% increase in the area under the plasma concentration versus time curve for fenoldopam. These data suggest that acetaminophen may significantly increase exposure to fenoldopam and increase its hypotensive effect. Data are available for orally administered fenoldopam only. Since fenoldopam is available as an intravenously administered drug for emergent hypertension, its dose can be rapidly titrated in cases of hypotension.
- Ziemniak JA, Allison N, Boppana VK, Dubb J, Stote R "The effect of acetaminophen on the disposition of fenoldopam: competition for sulfation." Clin Pharmacol Ther 41 (1987): 275-81
- Brogden RN, Markham A "Fenoldopam: a review of its pharmacodynamic and pharmacokinetic properties and intravenous clinical potential in the management of hypertensive urgencies and emergencies." Drugs 54 (1997): 634-50
Generic Name: acetaminophen / dextromethorphan / pseudoephedrine
Brand name: Alka-Seltzer Plus Flu Liquigels, Comtrex Non-Drowsy, Dayquil Liquicaps, Daytime Cold, Non-Drowsy Daytime, Robitussin Honey Flu Non-Drowsy, Theraflu Daytime Severe Cold, Theraflu Severe Cold & Congestion Non-Drowsy, Triaminic Cough & Sore Throat, Triaminic Softchew Throat Pain and Cough, Triaminic Softchews Cough & Sore Throat, EQL Severe Cold, GNP Day Time D Cold/Flu, PX Daytime Multi-Symptom, RA Acetaminophen Flu Cold
Synonyms: Acetaminophen, dextromethorphan, and pseudoephedrine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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