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Fenoldopam and Neoral

Determining the interaction of Fenoldopam and Neoral and the possibility of their joint administration.

Check result:
Fenoldopam <> Neoral
Relevance: 20.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data have shown that fenoldopam can improve renal function in patients with decreased renal function associated with the use of cyclosporine. (Cyclosporine causes renal vasoconstriction and reduced renal blood flow that may contribute to chronic nephrotoxicity.) The mechanism by which fenoldopam increases urine flow rate, fractional excretion of sodium, effective renal plasma flow, and glomerular filtration rate is probably related to its renal vasodilating abilities. This combination can be used to advantage.

References
  • Jorkasky DK, Audet P, Shusterman N, Ilson B, Dafoe D, Hedrich D, Stote RM "Fenoldopam reverses cyclosporine-induced renal vasoconstriction in kidney transplant recipients." Am J Kidney Dis 19 (1992): 567-72
Fenoldopam

Generic Name: fenoldopam

Brand name: Corlopam

Synonyms: n.a.

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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