FeroSul and Prepopik
Determining the interaction of FeroSul and Prepopik and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using magnesium oxide together with ferrous sulfate may decrease the effects of ferrous sulfate. Separate the administration of ferrous sulfate at least two hours apart from magnesium oxide. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The exact mechanism is unknown but may involve reduced iron solubility due to increase in gastric pH and/or reduced absorption due to complexation or precipitation of the iron. Based on existing data, sodium bicarbonate and calcium carbonate appear to have greater effects than antacids containing magnesium and aluminum hydroxides. In a study of patients with mild iron deficiency anemia, coadministration of ferrous sulfate with sodium bicarbonate 1 gram and calcium carbonate 500 mg reduced iron absorption by 50% and 67%, respectively, while 5 mL of an antacid containing magnesium and aluminum hydroxides had little effect. Another study also found no effect on iron absorption when ferrous sulfate (equivalent to 10 mg/kg of elemental iron) was coadministered with magnesium hydroxide (1 mg for every 5 mg of elemental iron ingested) in a group of healthy, fasting male subjects. In contrast, absorption of iron from ferrous sulfate and ferrous fumarate tablets was reduced by 37% and 31%, respectively, following administration of an antacid containing magnesium carbonate, magnesium hydroxide, and aluminum hydroxide in a study of healthy, iron-replete volunteers. Similarly, in a study of nine patients, coadministration of 5 mg of ferrous sulfate with a 35 gram dose of magnesium trisilicate was found to reduce iron absorption by an average of more than 70%. The interaction reportedly does not occur in the presence of ascorbic acid, which may competitively bind with iron and prevent the interference with iron absorption.
MANAGEMENT: To minimize the potential for interaction, it may be appropriate to administer oral iron preparations at least two hours apart from antacids or other agents with acid-neutralizing effects.
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- Wallace KL, Curry SC, LoVecchio F, Raschke R "Effect of magnesium hydroxide on iron absorption after ferrous sulfate." Ann Emerg Med 34 (1999): 685-6
- Snyder BK, Clark RF "Effect of magnesium hydroxide administration on iron absorption after a supratherapeutic dose of ferrous sulfate in human volunteers: A randomized controlled trial." Ann Emerg Med 33 (1999): 400-5
- Pruchnicki MC, Coyle JD, Hoshaw-Woodard S, Bay WH "Effect of phosphate binders on supplemental iron absorption in healthy subjects." J Clin Pharmacol 42 (2002): 1171-6
Generic Name: ferrous sulfate
Brand name: Feosol, Fer-Gen-Sol, Fer-in-Sol, Fer-Iron, FeroSul, Ferra TD. Caps, Ferro-Bob, Ferrousal, Lydia E. Pinkham, MyKidz Iron 10, Slow Fe, Slow Release Iron, Fe Caps, Feratab, Fer Iron, Fer-in-Sol, Ferra-TD
Synonyms: n.a.
Generic Name: citric acid / magnesium oxide / sodium picosulfate
Brand name: Clenpiq, Prepopik
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- FeroSul-PreQue 10 Tablets
- FeroSul-PreserVision AREDS
- FeroSul-PreserVision AREDS 2 Formula + Multivitamin
- FeroSul-PreserVision Lutein
- FeroSul-Prestalia
- FeroSul-PreTAB Tablets
- Prepopik-Ferotrin
- Prepopik-Ferra T.D. Caps
- Prepopik-Ferralet 90
- Prepopik-Ferralet 90 (Iron/Folic Acid/Cyanocobalamin/Vitamin C/Docusate)
- Prepopik-Ferralet 90 (Vitamins (Multiple/Oral))
- Prepopik-FerraPlus 90