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Ferus Pic-150 and Trientine Capsules

Determining the interaction of Ferus Pic-150 and Trientine Capsules and the possibility of their joint administration.

Check result:
Ferus Pic-150 <> Trientine Capsules
Relevance: 02.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Trientine can bind to iron in the gastrointestinal tract. This may inactivate the iron and also interfere with the absorption of trientine into the bloodstream. The effectiveness of both medications may be reduced. To avoid or minimize the interaction, the dosing times of trientine and iron polysaccharide (or any other iron-containing medication) should be separated by at least two hours. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: The oral bioavailability of trientine and iron or other minerals may be decreased during concurrent administration. The proposed mechanism is chelation of trientine by polyvalent cations, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract.

MANAGEMENT: In general, mineral supplements and other products containing minerals should not be used in patients treated with trientine. However, iron deficiency may develop, particularly in children and menstruating or pregnant women. If necessary, iron may be given in short courses, provided that administration times are separated by at least two hours.

References
  • "Product Information. Syprine (trientine)." Aton Pharma, Lawrenceville, NJ.
Ferus Pic-150

Generic Name: iron polysaccharide

Brand name: Ezfe, Ferrex-150, Ferus Pic-150, Iferex 150, Niferex Elixir, NovaFerrum 50, Nu-Iron 150, Poly Iron, ProFe, Myferon 150, Novaferrum, Poly-Iron, Fe-Tinic 150, Ferrex 150 Plus, Niferex-150

Synonyms: n.a.

Trientine Capsules

Generic Name: trientine

Brand name: Syprine, Clovique

Synonyms: Trientine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction