Fesoterodine Tablets and Pexeva

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

PARoxetine may increase the blood levels and effects of fesoterodine. You may need a dose adjustment if you have been taking fesoterodine and are starting treatment with PARoxetine. Let your doctor know if you experience excessive drowsiness, dizziness, irregular heartbeat, blurry vision, difficulty urinating, dry mouth, headache, gastrointestinal upset, or constipation while taking these medications, as they may be symptoms caused by excessive effects of fesoterodine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 2D6 may increase the plasma concentrations of fesoterodine's active metabolite, 5-hydroxymethyl tolterodine, which is partially metabolized by the isoenzyme. The interaction has not been examined in pharmacokinetic studies. In poor metabolizers of CYP450 2D6, representing maximum CYP450 2D6 inhibition, 5-hydroxymethyl tolterodine peak plasma concentration (Cmax) and systemic exposure (AUC) are increased 1.7- and 2-fold, respectively, relative to extensive metabolizers.

MANAGEMENT: No initial dosing adjustments are recommended when fesoterodine is used in combination with CYP450 2D6 inhibitors. Patients should be advised to notify their physician if they experience potential adverse effects of fesoterodine such as irregular heartbeat, blurry vision, difficulty urinating, dry mouth, headache, drowsiness, dizziness, gastrointestinal upset, or constipation.

Fesoterodine Tablets

Generic Name: fesoterodine

Brand name: Toviaz

Synonyms: Fesoterodine

What is Fesoterodine Tablets?

Pexeva

Generic Name: paroxetine

Brand name: Brisdelle, Paxil, Paxil CR, Pexeva

Synonyms: n.a.

What is Pexeva?