Fesoterodine Tablets and Phenytoin Capsules
Determining the interaction of Fesoterodine Tablets and Phenytoin Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin may reduce the blood levels and effects of fesoterodine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of fesoterodine's active metabolite, 5-hydroxymethyl tolterodine, which is partially metabolized by the isoenzyme. Following induction of CYP450 3A4 with rifampin 600 mg once a day, 5-hydroxymethyl tolterodine peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 70% and 75%, respectively, after oral administration of fesoterodine 8 mg. The effects of less potent CYP450 3A4 inducers were not examined.
MANAGEMENT: No dosing adjustments are recommended when fesoterodine is used with CYP450 3A4 inducers. However, the possibility of diminished therapeutic effects should be considered.
- "Product Information. Toviaz (fesoterodine)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Generic Name: fesoterodine
Brand name: Toviaz
Synonyms: Fesoterodine
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fesoterodine Tablets-Phenytoin Chewable Tablets
- Fesoterodine Tablets-Phenytoin Extended-Release Capsules
- Fesoterodine Tablets-Phenytoin Infatabs
- Fesoterodine Tablets-Phenytoin injection
- Fesoterodine Tablets-Phenytoin Intravenous
- Fesoterodine Tablets-Phenytoin Oral Suspension
- Phenytoin Capsules-Fetzima
- Phenytoin Capsules-Fetzima Titration
- Phenytoin Capsules-Fetzima Titration Pack
- Phenytoin Capsules-Feverall
- Phenytoin Capsules-Feverall rectal
- Phenytoin Capsules-Feverfew