Fexofenadine and pseudoephedrine and Fluconazole Injection
Determining the interaction of Fexofenadine and pseudoephedrine and Fluconazole Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with ketoconazole has been shown to significantly increase the oral bioavailability of fexofenadine. The proposed mechanism is ketoconazole inhibition of the intestinal efflux of fexofenadine via P-glycoprotein transporter. In 24 healthy volunteers, coadministration of fexofenadine 120 mg twice a day and ketoconazole 400 mg once a day resulted in a 135% and 164% increase in the steady-state fexofenadine peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to administration of fexofenadine alone. However, no increase in adverse effects or QTc interval were noted. No studies have been performed using other azole antifungal agents, but similar results are possible given their similarities to ketoconazole. Fexofenadine had no effect on the pharmacokinetics of ketoconazole.
- "Product Information. Allegra-D (fexofenadine-pseudoephedrine)." Chattem Consumer Products, Chattanooga, TN.
- "Product Information. Allegra (fexofenadine)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Generic Name: fexofenadine / pseudoephedrine
Brand name: Allegra-D 12 hour, Allegra-D 24 Hour, Allegra-D 12 Hour Allergy & Congestion, Allegra-D 24 Hour Allergy & Congestion, Allegra D OTC 24HR, Fexofenadine HCl-Pseudoephedrine 12 Hour, Antihistamine & Nasal Decongestant
Synonyms: Fexofenadine and Pseudoephedrine
Generic Name: fluconazole
Brand name: Diflucan
Synonyms: Fluconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fexofenadine and pseudoephedrine-Fluconazole Injection Solution
- Fexofenadine and pseudoephedrine-Fluconazole Intravenous
- Fexofenadine and pseudoephedrine-Fluconazole Oral Suspension
- Fexofenadine and pseudoephedrine-Fluconazole Tablets
- Fexofenadine and pseudoephedrine-Flucytosine
- Fexofenadine and pseudoephedrine-Fludara
- Fluconazole Injection-Fexofenadine Hydrochloride
- Fluconazole Injection-Fexofenadine Oral Suspension
- Fluconazole Injection-Fexofenadine Orally Disintegrating Tablets
- Fluconazole Injection-Fexofenadine Tablets
- Fluconazole Injection-Fiasp
- Fluconazole Injection-Fiasp (Insulin Aspart (Cartridges & Prefilled Pens) (Fiasp))