Fexofenadine Hydrochloride and Vfend

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with ketoconazole has been shown to significantly increase the oral bioavailability of fexofenadine. The proposed mechanism is ketoconazole inhibition of the intestinal efflux of fexofenadine via P-glycoprotein transporter. In 24 healthy volunteers, coadministration of fexofenadine 120 mg twice a day and ketoconazole 400 mg once a day resulted in a 135% and 164% increase in the steady-state fexofenadine peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to administration of fexofenadine alone. However, no increase in adverse effects or QTc interval were noted. No studies have been performed using other azole antifungal agents, but similar results are possible given their similarities to ketoconazole. Fexofenadine had no effect on the pharmacokinetics of ketoconazole.

Fexofenadine Hydrochloride

Generic Name: fexofenadine

Brand name: Allegra, Aller-Ease, Children's Allegra Allergy, Mucinex Allergy, Wal-Fex, Allegra ODT, Allegra 24 Hour Allergy, Allegra Allergy, Children's Allegra ODT, Allergy Relief, Allegra OTC

Synonyms: Fexofenadine

What is Fexofenadine Hydrochloride?

Vfend

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Vfend Injection

What is Vfend?