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Filgrastim-aafi Intravenous, Subcutaneous and Lithium Carbonate ER Tablets

Determining the interaction of Filgrastim-aafi Intravenous, Subcutaneous and Lithium Carbonate ER Tablets and the possibility of their joint administration.

Check result:

Filgrastim-aafi Intravenous, Subcutaneous <> Lithium Carbonate ER Tablets

Relevance: 13.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using filgrastim together with lithium. Combining these medications may increase the effects of filgrastim, which could lead to excessive numbers of certain types of blood cells. You may need a dose adjustment or more frequent monitoring of your blood cell counts to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Lithium may potentiate the myeloproliferative effects of colony-stimulating factors (CSF). In vitro and in vivo evidence suggests that lithium can induce the production and release of CSF in some patients, resulting in leukocytosis that is frequently due to neutrophilia. Significant increases in CD34+ cells and thrombocytes have also been reported.

MANAGEMENT: Patients receiving concomitant treatment with colony-stimulating factors and lithium may require more frequent monitoring of blood counts in order to avoid the potential complications of excessive leukocytosis.

References

Lapierre G, Stewart RB "Lithium carbonate and leukocytosis." Am J Hosp Pharm 37 (1980): 1525-8
"Product Information. Neupogen (filgrastim)." Amgen, Thousand Oaks, CA.
Reisberg B, Gershon S "Side effects associated with lithium therapy." Arch Gen Psychiatry 36 (1979): 879-87
Boggs DR, Joyce RA "The hematopoietic effects of lithium." Semin Hematol 20 (1983): 129-38
Harker WG, Rothstein G, Clarkson D, Athens JW, Macfarlane JL "Enhancement of colony-stimulating activity production by lithium." Blood 49 (1977): 263-7
Baldessarini RJ, Lipinski JF "Lithium salts: 1970-1975." Ann Intern Med 83 (1975): 527-33
"Product Information. Granix (tbo-filgrastim)." Teva Pharmaceuticals USA, North Wales, PA.
Ballin A, Lehman D, Sirota P, Litvinjuk U, Meytes D "Increased number of peripheral blood CD34+ cells in lithium-treated patients." Br J Haematol 100 (1998): 219-21
Ozdemir MA, Sofuoglu S, Tanrikulu G, Aldanmaz F, Esel E, Dundar S "Lithium-induced hematologic changes in patients with bipolar affective disorder." Biol Psychiatry 35 (1994): 210-3
Focosi D, Azzara A, Kast RE, Carulli G, Petrini M "Lithium and hematology: established and proposed uses." J Leukoc Biol 85 (2009): 20-8
McCormack JJ, Tseng CK, Marquez VE, Paull KE "INHIBITION STUDIES WITH PURINE NUCLEOSIDE PHOSPHORYLASE (MEETING ABSTRACT)." Proc Annu Meet Am Assoc Cancer Res 29 (1988): a1387
"Product Information. Neulasta (pegfilgrastim)." Amgen, Thousand Oaks, CA.
"Product Information. Leukine (sargramostim)." Immunex Corporation, Seattle, WA.

Filgrastim-aafi Intravenous, Subcutaneous

Generic Name: filgrastim

Brand name: Neupogen, Neupogen SingleJect, Nivestym, Zarxio

Synonyms: Filgrastim-aafi

What is Filgrastim-aafi Intravenous, Subcutaneous?

Lithium Carbonate ER Tablets

Generic Name: lithium

Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: Lithium

What is Lithium Carbonate ER Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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