Finasteride 1 mg Tablets and Tarazosin Capsules
Determining the interaction of Finasteride 1 mg Tablets and Tarazosin Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Study data (n=90) reported a statistically significant interaction between finasteride and terazosin affecting finasteride pharmacokinetics, but not those of terazosin. Treatment with terazosin (45 days) and finasteride (10 days) resulted in a finasteride Cmax and AUC(0-24) significantly greater than for finasteride alone. The clinical significance of this interaction remains to be determined. Earlier data (n=48) failed to reveal significant pharmacokinetic or pharmacodynamic alterations in either drug when administered concurrently. No special precautions are recommended at this time.
- Samara EE, Hosmane B, Locke C, Eason C, Cavanaugh J, Granneman GR "Assessment of the pharmacokinetic-pharmacodynamic interaction between terazosin and finasteride." J Clin Pharmacol 36 (1996): 1169-78
- Vashi V, Chung M, Hilbert J, Lawrence V, Phillips K "Pharmacokinetic interaction between finasteride and terazosin, but not finasteride and doxazosin." J Clin Pharmacol 38 (1998): 1072-6
Generic Name: finasteride
Brand name: Propecia, Proscar
Synonyms: Finasteride
Generic Name: terazosin
Brand name: Hytrin
Synonyms: Terazosin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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