Fingolimod Hydrochloride and Inlyta

• Generic Name: fingolimod
• Dosage Forms: n.a.
• Other Brand Names: Gilenya

Treatment of relapsing forms of MS (e.g., relapsing-remitting MS [RRMS]).

Fingolimod is one of several disease-modifying therapies used in the management of RRMS. Although not curative, these therapies have all been shown to modify several measures of disease activity, including relapse rates, new or enhancing magnetic resonance imaging (MRI) lesions, and disability progression.

The American Academy of Neurology (AAN) recommends that disease-modifying therapy be offered to patients with RRMS who have had recent relapses and/or MRI activity. Clinicians should consider adverse effects, tolerability, method of administration, safety, efficacy, and cost of the drugs in addition to patient preferences when selecting an appropriate therapy.

Additional studies needed to determine optimal role and safety profile of fingolimod, particularly during long-term use and in comparison with other disease-modifying therapies (e.g., glatiramer acetate, interferon beta, natalizumab).

May be useful in patients who prefer to avoid parenteral administration and/or those who have had an inadequate response to other disease-modifying therapies (e.g., dimethyl fumarate, glatiramer acetate, interferon beta, teriflunomide).

Has been evaluated, but currently not FDA-labeled for treatment of primary-progressive MS.

Designated an orphan drug by FDA for treatment of chronic inflammatory demyelinating polyneuropathy.

• Generic Name: axitinib
• Dosage Forms: tablet, film coated
• Other Brand Names: Inlyta

Inlyta (axitinib) is a prescription medicine that interferes with the growth of some cancer cells.

Inlyta is used to treat advanced kidney cancer (advanced renal cell carcinoma) when one prior drug treatment regimen for the kidney cancer has not worked.

It is not known if Inlyta is safe and effective in children.