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FIRST Baclofen and Flumazenil Injection

Determining the interaction of FIRST Baclofen and Flumazenil Injection and the possibility of their joint administration.

Check result:

FIRST Baclofen <> Flumazenil Injection

Relevance: 21.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Several case reports have suggested that flumazenil may counteract the central effects of baclofen while preserving its spinal effects. This interaction has been used clinically in the management of baclofen toxicity in a very small number of patients.

References

Saissy JM, Vitris M, Demaziere J, Seck M, Marcoux L, Gaye M "Flumazenil counteracts intrathecal baclofen-induced central nervous system depression in tetanus." Anesthesiology 76 (1992): 1051-3

FIRST Baclofen

Generic Name: baclofen

Brand name: Lioresal Intrathecal, Gablofen, FIRST Baclofen, Lioresal, Ozobax

Synonyms: Baclofen

What is FIRST Baclofen?

Flumazenil Injection

Generic Name: flumazenil

Brand name: Romazicon

Synonyms: Flumazenil

What is Flumazenil Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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