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First-Vancomycin 25 and Piperacillin and tazobactam

Determining the interaction of First-Vancomycin 25 and Piperacillin and tazobactam and the possibility of their joint administration.

Check result:

First-Vancomycin 25 <> Piperacillin and tazobactam

Relevance: 03.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Vancomycin may cause kidney problems, and combining it with other medications that can also affect the kidney such as piperacillin may increase that risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you experience signs and symptoms that may suggest kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: When administered concomitantly, vancomycin and piperacillin may have additive nephrotoxic effects. A limited number of retrospective studies have found an increased incidence of acute kidney injury in patients treated with vancomycin and piperacillin-tazobactam relative to vancomycin alone. No pharmacokinetic interactions have been noted between these agents.

MANAGEMENT: Caution is advised when vancomycin is used concomitantly with other nephrotoxic drugs such as piperacillin. Clinical and laboratory monitoring of renal function is recommended.

References

Hammond DA, Smith MN, Painter JT, Meena NK, Lusardi K "Comparative incidence of acute kidney injury in critically ill patients receiving vancomycin with concomitant piperacillin-tazobactam or cefepime: A restrospective cohort study." Pharmacotherapy 0 (2016): Epub
Cerner Multum, Inc. "Australian Product Information." O 0
Karino S, Kaye KS, Navalkele B, et.al "Epidemiology of acute kidney injury in critically ill patients receiving concomitant vancomycin and piperacillin/tazobactam: Opportunities for antimicrobial stewardship." Antimicrob Agents Chemother pii (2016): Epub
Moenster RP, Linneman TW, Finnegan PM, Hand S, Thomas Z, McDonald JR "Acute renal failure associated with vancomycin and â-lactams for the treatment of osteomyelitis in diabetics: piperacillin-tazobactam as compared with cefepime." Clin Microbiol Infect 2013 (2014): O384-9
Reed EE, Johnston J, Severing J, Stevenson KB, Deutscher M "Nephrotoxicity risk factors and intravenous vancomycin dosing in the immediate postoperative period following antibiotic-impregnated cement spacer replacement." Ann Pharmacother 48 (2014): 962-9
Meaney CJ, Hynicka LM, Tsoukleris MG "Vancomycin-associated nephrotoxicity in adult medicine patients: incidence, outcomes, and risk factors." Pharmacotherapy 34 (2014): 653-61
Gomes DM, Smotherman C, Birch A, et. al "Comparison of acute kidney injury during treatment with vancomycin in combination with piperacillin-tazobactam or cefepime." Pharmacotherapy 34 (2014): 662-9
Peyko V, Smalley S, Cohen H "Prospective comparison of acute kidney injury during treatment with the combination of piperacillin-tazobactam and vancomycin versus the combination of cefepime or meropenem and vancomycin." J Pharm Pract pii (2016): Epub
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Burgess LD, Drew RH "Comparison of the incidence of vancomycin-induced nephrotoxicity in hospitalized patients with and without concomitant piperacillin-tazobactam." Pharmacotherapy 34 (2014): 670-6
Kim T, Kandiah S, Patel, M, et.al "Risk factors for kidney injury during vancomycin and piperacillin/tazobactam administration, including increased odds of injury with combination therapy." BMC Res Notes 8 (2015): 579

First-Vancomycin 25

Generic Name: vancomycin

Brand name: FIRST-Vancomycin, Vancocin HCl Pulvules, First-Vancomycin 25, First-Vancomycin 50, Firvanq, Vancocin, First-Vancomycin 25, First-Vancomycin 50

Synonyms: Vancomycin

What is First-Vancomycin 25?

Piperacillin and tazobactam

Generic Name: piperacillin / tazobactam

Brand name: Zosyn

Synonyms: Piperacillin and Tazobactam

What is Piperacillin and tazobactam?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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