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First-Vancomycin 50 and Tobi

Determining the interaction of First-Vancomycin 50 and Tobi and the possibility of their joint administration.

Check result:

First-Vancomycin 50 <> Tobi

Relevance: 13.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Tobramycin can cause hearing loss, ringing in the ears, vertigo, and kidney problems, and combining it with vancomycin may increase the risks. Patients who may be particularly susceptible include the elderly and those who are dehydrated or have preexisting kidney disease. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: When administered concomitantly, glycopeptide antibiotics and parenteral aminoglycosides or oral neomycin may have additive nephrotoxic or neurotoxic effects.

MANAGEMENT: If these drugs must be used together, renal function and serum drug concentrations should be monitored.

References

Farber BF, Moellering RC Jr "Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981." Antimicrob Agents Chemother 23 (1983): 138-41
Odio C, McCracken GH, Nelson JD "Nephrotoxicity associated with vancomycin-aminoglycoside therapy in four children." J Pediatr 105 (1984): 491-2
Pauly DJ, Musa DM, Lestico MR, Lindstrom MJ, Hetsko CM "Risk of nephrotoxicity with combination vancomycin-aminoglycoside antibiotic therapy." Pharmacotherapy 10 (1990): 378-82
Sorrell TC, Collignon PJ "A prospective study of adverse reactions associated with vancomycin therapy." J Antimicrob Chemother 16 (1985): 235-41
Downs NJ, Neihart RE, Dolezal JM, Hodges GR "Mild nephrotoxicity associated with vancomycin use." Arch Intern Med 149 (1989): 1777-81
Dean RP, Wagner DJ, Tolpin MD "Vancomycin/aminoglycoside nephrotoxicity." J Pediatr 106 (1985): 861-2

First-Vancomycin 50

Generic Name: vancomycin

Brand name: FIRST-Vancomycin, Vancocin HCl Pulvules, First-Vancomycin 25, First-Vancomycin 50, Firvanq, Vancocin, First-Vancomycin 25, First-Vancomycin 50

Synonyms: Vancomycin

What is First-Vancomycin 50?

Tobi

Generic Name: tobramycin

Brand name: Bethkis, Kitabis Pak, Tobi, TOBI Podhaler

Synonyms: Tobi (inhalation)

What is Tobi?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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