Flagyl and Nateglinide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

MetroNIDAZOLE may increase the blood levels of nateglinide. This can increase the risk of side effects such as hypoglycemia, or low blood sugar. Symptoms include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 2C9 may increase the plasma concentrations of nateglinide, which is primarily metabolized by the isoenzyme. In 18 healthy volunteers, administration of a single 120 mg oral dose of nateglinide in combination with the CYP450 2C9 inhibitor sulfinpyrazone (200 mg orally twice daily for 7 days) increased mean sulfinpyrazone systemic exposure (AUC) by 28% compared to administration alone. Sulfinpyrazone did not affect the mean peak plasma concentration (Cmax), time to reach peak plasma concentration (Tmax), or the elimination half-life of nateglinide.

MANAGEMENT: Because the antidiabetic effect of nateglinide is dose- and concentration-dependent, close monitoring for the development of hypoglycemia is recommended during coadministration with CYP450 2C9 inhibitors. Patients should regularly monitor their blood sugar and learn how to recognize and treat hypoglycemia, which may include symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitation. The dosage of nateglinide may require adjustment if an interaction is suspected. Likewise, patients should be observed for potential loss of glycemic control following discontinuation of the CYP450 2C9 inhibitor, and the nateglinide dosage adjusted as necessary.

Flagyl

Generic Name: metronidazole

Brand name: Flagyl, FIRST Metronidazole, Flagyl 375, MetroGel

Synonyms: n.a.

What is Flagyl?

Nateglinide

Generic Name: nateglinide

Brand name: Starlix

Synonyms: n.a.

What is Nateglinide?