Flagyl and Rifabutin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using rifabutin together with metroNIDAZOLE may decrease the effects of metroNIDAZOLE. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with a rifamycin may decrease the plasma concentrations of nitroimidazoles. The proposed mechanism is rifamycin induction of nitroimidazole metabolism via hepatic microsomal enzymes. The interaction has been reported with rifampin and metronidazole. In ten healthy volunteers, rifampin (450 mg daily for 7 days) decreased the area under the plasma concentration-time curve (AUC) of metronidazole (500 mg or 1000 mg single intravenous dose) by 33% and increased its clearance by 44% compared to administration of metronidazole alone. No data are available for tinidazole.

MANAGEMENT: Pharmacologic response to metronidazole should be monitored more closely during coadministration with a rifamycin, and the dosage adjusted as necessary. Given its structural similarities to metronidazole, the same precaution may be applicable during therapy with tinidazole, although clinical data are lacking.

Flagyl

Generic Name: metronidazole

Brand name: Flagyl, FIRST Metronidazole, Flagyl 375, MetroGel

Synonyms: n.a.

What is Flagyl?

Rifabutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Rifabutin?