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Flecainide and Inderal

Determining the interaction of Flecainide and Inderal and the possibility of their joint administration.

Check result:

Flecainide <> Inderal

Relevance: 25.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using propranolol together with flecainide may have additive effects. Contact your doctor if you experience dizziness, slow or irregular heartbeats, fainting, or palpitations. You may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Beta-blockers and flecainide may have additive negative inotropic effects. Areas under the curve were increased for both drugs and negative inotropic effects occurred when flecainide and propranolol were given to normal subjects. A case of bradycardia, atrioventricular block and cardiac arrest has been reported after sotalol was added to flecainide; however, causality was not definitely determined.

MANAGEMENT: Careful monitoring of the patient's hemodynamic status is recommended during concomitant administration. The same precaution should be observed when beta blocker ophthalmic solutions are used, since they are systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels. Patients should be advised to promptly report symptoms such as dizziness, slow or irregular heartbeats, syncope, or palpitations.

References

Lewis GP, Holtzman JL "Interaction of flecainide with digoxin and propranolol." Am J Cardiol 53 (1984): b52-7
Minish T, Herd A "Symptomatic bradycardia secondary to interaction between topical timolol maleate, verapamil, and flecainide: a case report." J Emerg Med 22 (2002): 247-9
Holtzman JL, Kvam DC, Berry DA, et al "The pharmacodynamic and pharmacokinetic interaction of flecainide acetate with propranolol: effects on cardiac function and drug clearance." Eur J Clin Pharmacol 33 (1987): 97-9
Myerburg RJ, Kessler KM, Cox MM, et al "Reversal of proarrhythmic effects of flecainide acetate and encainide hydrochloride by propranolol." Circulation 80 (1989): 1571-9
Warren R, Vohra J, Hunt D, Hamer A "Serious interactions of sotalol with amiodarone and flecainide." Med J Aust 152 (1990): 277

Flecainide

Generic Name: flecainide

Brand name: Tambocor

Synonyms: n.a.

What is Flecainide?

Inderal

Generic Name: propranolol

Brand name: Inderal LA, Inderal XL, InnoPran XL, Inderal, Hemangeol, InnoPran XL

Synonyms: n.a.

What is Inderal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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