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Flecainide and Quin-G

Determining the interaction of Flecainide and Quin-G and the possibility of their joint administration.

Check result:
Flecainide <> Quin-G
Relevance: 25.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using flecainide together with quiNIDine may increase the effects of flecainide. Contact your doctor if you experience tiredness, dizziness, confusion, difficulty breathing, heart attack, and a worsening irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Quinidine may decrease the CYP450 2D6 hepatic metabolism of flecainide in some patients. Serum flecainide levels and the risk of toxicity may be increased. Extensive debrisoquine metabolizers may be at greater risk of toxicity.

MANAGEMENT: Patients should be monitored for flecainide side effects and ECG changes after quinidine is added to the regimen. A reduction in flecainide dosage may be necessary. Patients should be advised to notify their physician if they experience dizziness, confusion, nausea, vomiting, syncope, blurry vision, changes in pulse rate, or increased irregular heartbeats.

References
  • Munafo A, Buclin T, Steinhausen F, Biollaz J "Disposition of flecainide in subjects taking quinidine." Clin Pharmacol Ther 47 (1990): 156
  • Munafo A, Buclin T, Tuto D, Biollaz J "The effect of a low dose of quinidine on the disposition of flecainide in healthy volunteers." Eur J Clin Pharmacol 43 (1992): 441-3
Flecainide

Generic Name: flecainide

Brand name: Tambocor

Synonyms: n.a.

Quin-G

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction