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Flexeril and Ismelin

Determining the interaction of Flexeril and Ismelin and the possibility of their joint administration.

Check result:

Flexeril <> Ismelin

Relevance: 16.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cyclobenzaprine together with guanethidine may decrease the effects of guanethidine. Contact your doctor if your condition changes or if your blood pressure increases. If your doctor does prescribe these medications together, you may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The manufacturer of cyclobenzaprine reports that it may block the antihypertensive effects of guanethidine. Loss of blood pressure control may result. The mechanism is unknown but may be related to inhibition of guanethidine uptake into adrenergic neurons.

MANAGEMENT: If patients receive this combination, their blood pressure should be closely monitored when initiating or discontinuing either drug. Either a different muscle relaxant or a different antihypertensive agent may be considered.

References

"Product Information. Flexeril (cyclobenzaprine)." Merck & Co, Inc, West Point, PA.

Flexeril

Generic Name: cyclobenzaprine

Brand name: Amrix, Fexmid, Flexeril, Comfort Pac with Cyclobenzaprine

Synonyms: n.a.

What is Flexeril?

Ismelin

Generic Name: guanethidine

Brand name:

Synonyms: Ismelin (Oral)

What is Ismelin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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