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Flomax and Phenoxybenzamine Capsules

Determining the interaction of Flomax and Phenoxybenzamine Capsules and the possibility of their joint administration.

Check result:
Flomax <> Phenoxybenzamine Capsules
Relevance: 01.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenoxybenzamine together with tamsulosin is not recommended. Combining these medications may cause blood pressure to fall excessively and heart rate to increase, especially when you rise from a sitting or lying position. The risk of other side effects such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) may also increase. These side effects can occur with either medication alone and are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away on their own or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medication affects you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Additive pharmacodynamic effects may be expected when relatively selective alpha-1A adrenoreceptor antagonists are coadministered with other alpha-blockers. Clinical data have not been reported, but there may be an increased risk and/or severity of adverse effects related to blockade of alpha-1 adrenergic receptors in the peripheral vasculature such as postural hypotension, dizziness, headache, syncope, priapism, and nasal congestion. These effects have occurred with alpha-1A adrenoreceptor antagonists even when given alone for the treatment of benign prostatic hyperplasia, despite relative selectivity for the 1A subtype of alpha-1 adrenoreceptors located in prostatic and bladder tissues.

MANAGEMENT: The use of relatively selective alpha-1A adrenoreceptor antagonists in combination with other alpha-blockers should be avoided.

References
  • "Product Information. Flomax (tamsulosin)." Boehringer-Ingelheim, Ridgefield, CT.
  • "Product Information. Rapaflo (silodosin)." Watson Pharmaceuticals, Corona, CA.
Flomax

Generic Name: tamsulosin

Brand name: Flomax

Synonyms: n.a.

Phenoxybenzamine Capsules

Generic Name: phenoxybenzamine

Brand name: Dibenzyline

Synonyms: Phenoxybenzamine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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