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Floxin Tablets and Theo-Dur

Determining the interaction of Floxin Tablets and Theo-Dur and the possibility of their joint administration.

Check result:

Floxin Tablets <> Theo-Dur

Relevance: 17.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using theophylline together with ofloxacin can increase the effects of theophylline. You should contact your doctor if you experience nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or an irregular heartbeat. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor

Professional:

MONITOR: Some fluoroquinolones have been shown to decrease the hepatic metabolism of theophyllines. The mechanism is inhibition of CYP450 1A2 hepatic metabolism. Patients with chronic obstructive pulmonary disease, congestive heart failure, or cirrhosis may have slower theophylline clearance rates; therefore, they may be at greater risk of developing theophylline toxicity. This drug combination may increase the risk of seizures, especially in the elderly. Interpatient variability of this effect makes it prudent to monitor patients who may not tolerate a small increase in theophylline levels during concurrent fluoroquinolone therapy.

MANAGEMENT: Interpatient variability of this effect makes it prudent to monitor patients who may not tolerate a small increase in theophylline levels. Levofloxacin, sparfloxacin, and lomefloxacin have been reported to cause minor or no changes in theophylline levels and may be considered as alternatives. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or irregular heartbeat to their physicians.

References

Davis RL, Kelly HW, Quenzer RW, Standefer J, Steinberg B, Gallegos J "Effect of norfloxacin on theophyllin metabolism." Antimicrob Agents Chemother 33 (1989): 212-4
Grasela TH, Dreis MW "An evaluation of the quinolone-theophylline interaction using the Food and Drug Administration spontaneous reporting system." Arch Intern Med 152 (1992): 617-21
Wijnands WJ, Vree TB "Interaction between the fluoroquinolones and the bronchodilator theophylline." J Antimicrob Chemother 22 (1988): 109-14
"Product Information. Cinobac (cinoxacin)." Oclassen Pharmaceuticals Inc, San Rafael, CA.
Bowles SK, Popovski Z, Rybak MJ, Beckman HB, Edwards DJ "Effect of norfloxacin on theophylline pharmacokinetics at steady state." Antimicrob Agents Chemother 32 (1988): 510-12
Sano M, Yamamoto I, Ueda J, Yoskikawa E, Yamashina H, Goto M "Comparative pharmacokinetics of theophylline following two fluoroquinolones co-administration." Eur J Clin Pharmacol 32 (1987): 431-2
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80
Wijnands WJ, Vree TB, Baars AM, van Herwaarden CL "Steady-state kinetics of the quinolone derivatives ofloxacin, enoxacin, ciprofloxacin and pefloxacin during maintneance treatment with theophylline." Drugs 34 (1987): 159-69
Raoof S, Wollschlager C, Khan FA "Ciprofloxacin increases serum levels of theophylline." Am J Med 82 (1987): 115-8
Hooper DC, Wolfson JS "The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans." Antimicrob Agents Chemother 28 (1985): 716-21
Covelli HD, Knodel AR, Heppner BT "Predisposing factors to apparent theophylline-induced seizures." Ann Allergy 54 (1985): 411-5
Ball P "Ciprofloxacin: an overview of adverse experiences." J Antimicrob Chemother 18 (1986): 187-93
Ho G, Tierney MG, Dales RE "Evaluation of the effect of norfloxacin on the pharmacokinetics of theophylline." Clin Pharmacol Ther 44 (1988): 35-8
Green L, Clark J "Fluoroquinolones and theophylline toxicity: norfloxacin." JAMA 262 (1989): 2383
Gregoire SL, Grasela TH Jr, Freer JP, Tack KJ, Schentag JJ "Inhibition of theophylline clearance by coadministered ofloxacin without alteraction of theophylline effects." Antimicrob Agents Chemother 31 (1987): 375-8
Segev S. Rehavi M, Rubinstein E "Quinolones, theophylline, and diclofenac interactions with the gamma-aminobutyric acid receptor." Antimicrob Agents Chemother 32 (1988): 1624-6

Floxin Tablets

Generic Name: ofloxacin

Brand name: Floxin, Floxin IV.

Synonyms: Floxin

What is Floxin Tablets?

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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