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Fluarix Quadrivalent 2015-2016 Formula and Zostavax

Determining the interaction of Fluarix Quadrivalent 2015-2016 Formula and Zostavax and the possibility of their joint administration.

Check result:
Fluarix Quadrivalent 2015-2016 Formula <> Zostavax
Relevance: 28.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The safety and efficacy of concomitant administration of varicella-zoster virus (VZV) vaccine and trivalent inactivated influenza vaccine in adults aged 50 and older were demonstrated in a large randomized, controlled study conducted at 20 sites in the U.S. and Europe. The study compared 382 subjects who received the vaccines simultaneously at separate injection sites (vaccines on day one; placebo at week 4) to 380 subjects who received them sequentially (influenza vaccine and placebo on day one; VZV vaccine at week 4) and found no significant difference in antibody responses between the two groups. Four weeks postvaccination, VZV antibody geometric mean titers were 554 gpELISA units/mL for the concomitant group and 597 gpELISA units/mL for the sequential group. The estimated geometric mean titre ratios (concomitant/sequential) were 0.9 for influenza A (H1N1), 1.1 for influenza A (H3N2), and 0.9 for influenza B according to hemagglutination inhibition assay. Both concomitant and sequential administration were generally well tolerated, with a similar overall incidence of systemic adverse events of approximately 33% and vaccine-related systemic adverse events of approximately 5% within four weeks postvaccination.

References
  • Kerzner B, Murray AV, Cheng E, et al. "Safety and immunogenicity profile of the concomitant administration of ZOSTAVAX and inactivated influenza vaccine in adults aged 50 and older." J Am Geriatr Soc 55 (2007): 1499-507
  • "Product Information. Zostavax (zoster vaccine live)." Merck & Company Inc, West Point, PA.
Fluarix Quadrivalent 2015-2016 Formula

Generic Name: influenza virus vaccine, inactivated

Brand name: Afluria, Agriflu, Fluad 2019-2020, Fluarix, Flublok Quadrivalent 2019-2020, Flucelvax, FluLaval, Fluogen, Flushield, Fluvirin, Fluzone, Flucelvax, Fluzone Intradermal Quadrivalent, Fluzone Quadrivalent, Flublok, Flublok Quadrivalent

Synonyms: Influenza virus vaccine (injection), Influenza Virus Vaccine (Inactivated)

Zostavax

Generic Name: zoster vaccine live

Brand name: Zostavax

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.