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Flublok Quadrivalent and Theo-Dur

Determining the interaction of Flublok Quadrivalent and Theo-Dur and the possibility of their joint administration.

Check result:

Flublok Quadrivalent <> Theo-Dur

Relevance: 23.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that administration of split, trivalent influenza vaccine may cause a transient reduction in theophylline clearance. However, further studies have not been able to reproduce this interaction. Patients should be monitored for possible theophylline toxicity following influenza vaccination. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.

References

Gomolin IH, Chapron DJ, Luhan PA "Lack of effect of influenza vaccine on theophylline levels and warfarin anticoagulation in the elderly." J Am Geriatr Soc 33 (1985): 269-72
Patriarca PA, Kendal AP, Stricof RL, Weber JA, Meissner MK, Dateno B "Influenza vaccination and warfarin or theophylline toxicity in nursing home patients." N Engl J Med 308 (1983): 1601-2
Grabowski N, May JJ, Pratt DS, Richtsmeier WJ, Bertino Jr JS "The effect of split virus influenza vaccination on theophylline pharmacokinetics." Am Rev Respir Dis 131 (1985): 934-8
Bukowskyj M, Munt PW, Wigle R, Nakatsu K "Theophylline clearance: lack of effect of influenza vaccination and ascorbic acid." Am Rev Respir Dis 129 (1984): 672-5
Meredith CG, Christian CD, Johnson RF, Troxell R, Davis GL, Schenker S "Effects of influenza virus vaccine on hepatic drug metabolism." Clin Pharmacol Ther 37 (1985): 396-401
Winstanley PA, Tjia J, Back DJ, Hobson D, Breckenridge AM "Lack of effect of highly purified subunit influenza vaccination on theophylline metabolism." Br J Clin Pharmacol 20 (1985): 47-53
Renton KW, Gray JD, Hall RI "Decreased elimination of theophylline after influenza vaccination." Can Med Assoc J 123 (1980): 288-90
Jonkman JHG, Wymenga ASC, de Zeeuw RA, et al. "No effect of influenza vaccination on theophylline pharmacokinetics as studied by ultraviolet spectrophotometry, HPLC, and EMIT assay methods." Ther Drug Monit 10 (1988): 345-48

Flublok Quadrivalent

Generic Name: influenza virus vaccine, inactivated

Brand name: Afluria, Agriflu, Fluad 2019-2020, Fluarix, Flublok Quadrivalent 2019-2020, Flucelvax, FluLaval, Fluogen, Flushield, Fluvirin, Fluzone, Fluad, Flublok, FluLaval Quadrivalent, Afluria Quadrivalent, Fluarix Quadrivalent, Flucelvax Quadrivalent, FluShield, Fluzone SV, Fluzone WV, Fluzone PFS, Fluzone Preservative-Free Pediatric, Fluzone Preservative-Free, Fluvirin Preservative-Free, Afluria Preservative-Free, FluLaval 2010-2011, Afluria 2010-2011, Fluzone 2010-2011, Fluvirin 2010-2011, Afluria Preservative-Free 2010-2011, Fluzone Preservative-Free 2010-2011, Fluzone Preservative-Free Pediatric 2010-2011, Fluarix 2010-2011, Fluvirin Preservative-Free 2010-2011, Fluzone High-Dose 2010-2011, Fluzone 2011-2012, Fluzone Preservative-Free 2011-2012, Fluvirin Preservative-Free 2011-2012, Fluvirin 2011-2012, Afluria Preservative-Free 2011-2012, Afluria 2011-2012, Fluarix 2011-2012, Fluzone Preservative-Free Pediatric 2011-2012, Fluzone High-Dose 2011-2012, Fluzone Intradermal 2011-2012, FluLaval 2011-2012, Fluzone Preservative-Free Pediatric 2012-2013, Fluzone 2012-2013, Fluzone Preservative-Free 2012-2013, Fluvirin Preservative-Free 2012-2013, Fluvirin 2012-2013, Afluria Preservative-Free 2012-2013, Afluria 2012-2013, Agriflu 2012-2013, Fluarix 2012-2013, FluLaval 2012-2013, Fluzone High-Dose 2012-2013, Fluzone Intradermal 2012-2013, Flucelvax 2012-2013, FluLaval 2013-2014, Afluria 2013-2014, Afluria Preservative-Free 2013-2014, Fluzone 2013-2014, Fluzone Preservative-Free 2013-2014, Fluzone Preservative-Free Pediatric 2013-2014, Fluzone High-Dose 2013-2014, Fluzone Intradermal 2013-2014, Fluvirin 2013-2014, Fluvirin Preservative-Free 2013-2014, Flucelvax 2013-2014, Flublok 2012-2013, Fluzone Preservative-Free Quadrivalent 2013-2014, Fluzone Preservative-Free Pediatric Quadrivalent 2013-2014, Fluarix 2013-2014, Fluarix Quadrivalent 2013-2014, FluLaval Quadrivalent 2013-2014, Flublok 2013-2014, Fluzone 2014-2015, FluLaval 2014-2015, Fluvirin 2014-2015, Afluria 2014-2015, Fluzone Preservative-Free 2014-2015, Fluvirin Preservative-Free 2014-2015, Afluria Preservative-Free 2014-2015, Fluzone Preservative-Free Pediatric Quadrivalent 2014-2015, Fluzone Preservative-Free Quadrivalent 2014-2015, Fluarix Quadrivalent 2014-2015, FluLaval Quadrivalent 2014-2015, Flucelvax 2014-2015, Fluzone High-Dose 2014-2015, Fluzone Intradermal 2014-2015, Fluzone Quadrivalent 2014-2015, Flublok 2014-2015, FluLaval Preservative-Free Quadrival, Flublok Quadrivalent

Synonyms: Flublok Quadrivalent 2019-2020 (injection)

What is Flublok Quadrivalent?

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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