Fluconazole and Hydrochlorothiazide and spironolactone
Determining the interaction of Fluconazole and Hydrochlorothiazide and spironolactone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The concomitant use of oral fluconazole and hydrochlorothiazide may increase the plasma concentrations of fluconazole. The proposed mechanism is reduced renal clearance of fluconazole. The clinical significance is unknown. This interaction is not expected to be relevant with single-dose regimens of fluconazole.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Diflucan (fluconazole)." Roerig Division, New York, NY.
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: hydrochlorothiazide / spironolactone
Brand name: Aldactazide
Synonyms: Hydrochlorothiazide and Spironolactone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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