Fluconazole in Dextrose Injection and Osphena

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using ospemifene together with fluconazole. Combining these medications may increase the blood levels and effects of ospemifene. This may increase the risk of side effects such as hot flush, blood clots, heart attack, stroke, and breast or endometrial cancer. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with fluconazole may significantly increase the plasma concentrations of ospemifene. The proposed mechanism is fluconazole inhibition of ospemifene metabolism via CYP450 3A4, 2C9, and 2C19. In 14 postmenopausal women given fluconazole 400 mg once followed by 200 mg daily for a total duration of 8 days, administration of ospemifene 60 mg after breakfast on day 5 of fluconazole treatment resulted in 1.7- and 2.7-fold increases in ospemifene peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to administration of ospemifene alone. Increased risk of adverse events such as hot flush, thromboembolism, and endometrial or breast cancer may occur.

MANAGEMENT: Ospemifene should not be prescribed in combination with fluconazole.

Fluconazole in Dextrose Injection

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Fluconazole

What is Fluconazole in Dextrose Injection?

Osphena

Generic Name: ospemifene

Brand name: Osphena

Synonyms: n.a.

What is Osphena?