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Fluconazole Intravenous and Gengraf Capsules

Determining the interaction of Fluconazole Intravenous and Gengraf Capsules and the possibility of their joint administration.

Check result:

Fluconazole Intravenous <> Gengraf Capsules

Relevance: 23.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with fluconazole may increase the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, fatigue, or headache. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Fluconazole may inhibit the CYP450 3A4 hepatic and/or gut wall metabolism of cyclosporine. Serum cyclosporine concentrations and risk of toxicity may be increased, although the data are conflicting. This interaction may be more likely with higher doses of fluconazole (more than 200 mg per day).

MANAGEMENT: If concomitant therapy is necessary, serum cyclosporine levels and renal function should be closely monitored. Dosage adjustments may be required. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, fatigue, or headache.

References

Kruger HU, Schuler U, Zimmerman R, Ehninger G "Absence of significant interaction of fluconazole with cyclosporin." J Antimicrob Chemother 24 (1989): 781-6
Osowski CL, Dix SP, Lin LS, Mullins RE, Geller RB, Wingard JR "Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients." Transplantation 61 (1996): 1268-72
Back D, Tjia J "Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes." Br J Clin Pharmacol 32 (1991): 624-6
Sugar AM, Saunders C, Idelson BA, Bernard DB "Interaction of fluconazole and cyclosporine." Ann Intern Med 110 (1989): 844
Canafax DM, Graves NM, Hilligoss DM, Carleton BC, Gardner MJ, Matas AJ "Increased cyclosporine levels as a result of simultaneous fluconazole and cyclosporine therapy in renal transplant recipients: a double-blind, randomized pharmacokinetic and safety study." Transplant Proc 23 (1991): 1041-2
Lopez-Gil JA "Fluconazole-cyclosporin interaction: a dose-dependent effect?" Ann Pharmacother 27 (1993): 427-30
Torregrosa V, De la Torre M, Campistol JM, et al "Interaction of fluconazole with ciclosporin A." Nephron 60 (1992): 125-6
Ehninger G, Jaschonek K, Schuler U, Kruger HU "Interaction of fluconazole with cyclosporin." Lancet 2 (1989): 104-5
Canafax DM, Graves NM, Hilligoss DM, et al "Interaction between cyclosporine and fluconazole in renal allograft recipients." Transplantation 51 (1991): 1014-8
"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.

Fluconazole Intravenous

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Fluconazole

What is Fluconazole Intravenous?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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