Fluconazole Tablets and Irbesartan
Determining the interaction of Fluconazole Tablets and Irbesartan and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The concomitant administration of fluconazole may modestly increase irbesartan concentrations. The proposed mechanism is inhibition of CYP450 2C9 mediated metabolism by fluconazole. After irbesartan 150 mg/day and fluconazole 200 mg/day were administered concurrently for 10 days to healthy subjects (n=15), mean irbesartan maximum plasma concentrations (Cmax) increased by 19% and areas under the concentration-time curve (AUC) increased by 63%. The clinical significance is unknown.
- Marino MR, Vachharajani NN "Drug interactions with irbesartan." Clin Pharmacokinet 40 (2001): 605-14
- Kovacs SJ, Wilton JH, Blum RA "Steady state (SS) pharmacokinetics (PK) of irbesartan alone and in combination with fluconazole." Clin Pharmacol Ther 65 (1999): 132
Generic Name: fluconazole
Brand name: Diflucan
Synonyms: Fluconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fluconazole Tablets-Irbesartan and Hydrochlorothiazide
- Fluconazole Tablets-Ircon
- Fluconazole Tablets-Irenka
- Fluconazole Tablets-Iressa
- Fluconazole Tablets-Iressa Oral
- Fluconazole Tablets-Irinotecan
- Irbesartan-Flucytosine
- Irbesartan-Fludara
- Irbesartan-Fludara injection
- Irbesartan-Fludarabine
- Irbesartan-Fludarabine injection
- Irbesartan-Fludarabine Intravenous