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Flumazenil and Silenor

Determining the interaction of Flumazenil and Silenor and the possibility of their joint administration.

Check result:

Flumazenil <> Silenor

Relevance: 25.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using doxepin together with flumazenil. Taking these drugs together can affect the rhythm of your heart and possibly cause seizures. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision, nausea, and seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Severe adverse effects, including fatalities, have been reported following the administration of flumazenil to multiple-drug-overdose patients who have taken large quantities of tricyclic antidepressants. The effects have included seizures and arrhythmias (including ventricular tachycardia). The mechanism of this interaction may be related to a decrease in the protective antiseizure effects of benzodiazepines that patients may have taken concomitantly with overdoses of tricyclic antidepressants.

MANAGEMENT: Administration of flumazenil should be avoided in patients who are known or suspected to have received overdoses of tricyclic antidepressants.

References

Marchant B, Wray R, Leach A, Nama M "Flumazenil causing convulsions and ventricular tachycardia." BMJ 299 (1989): 860
Mordel A, Winkler E, Almog S, Tirosh M, Ezra D "Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose." Crit Care Med 20 (1992): 1733-4
Lheureux P, Vrankx M, Askenasi R "Administration of flumazenil." Ann Emerg Med 20 (1991): 592-3
"Flumazenil." Med Lett Drugs Ther 34 (1992): 66-8
Geller E, Crome P, Schaller MD, Marchant B, Ectors M, Scollo-Lavizzari G "Risks and benefits of therapy with flumazenil (Anexate) in mixed drug intoxications." Eur Neurol 31 (1991): 241-50
Bodenham AR "Death after flumazenil." BMJ 299 (1989): 457

Flumazenil

Generic Name: flumazenil

Brand name: Romazicon

Synonyms: n.a.

What is Flumazenil?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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