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FluMist Quadrivalent and Virazole

Determining the interaction of FluMist Quadrivalent and Virazole and the possibility of their joint administration.

Check result:

FluMist Quadrivalent <> Virazole

Relevance: 06.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Antiviral flu medications like ribavirin may interfere with the immune response to influenza virus vaccine, live. Individuals who have been treated with antiviral flu medications should generally not be vaccinated with influenza virus vaccine, live until 24 to 48 hours after stopping treatment. The immunizing doctor should be informed of recent therapy with ribavirin so that appropriate measures and/or precautions can be taken. Similarly, individuals who have been vaccinated with influenza virus vaccine, live must generally wait two weeks before using antiviral flu medications unless otherwise directed by their doctor. If vaccination was given shortly before or during treatment with an antiviral flu medication, a revaccination may be necessary at some point. It is important to tell the doctor about all other medications being used, including vitamins and herbs. Do not stop using any medications without first talking to the doctor.

Professional:

ADJUST DOSING INTERVAL: Antiviral agents that are active against influenza A and/or B viruses may conceivably interfere with the immunogenicity of live influenza virus vaccine by inhibiting the replication of vaccine virus. However, the potential for interaction has not been evaluated.

MANAGEMENT: Live influenza virus vaccine should not be administered until at least 48 hours after the cessation of antiviral therapy. Antiviral agents should not be administered until two weeks after immunization with live influenza virus vaccine unless medically indicated. If antiviral agents and live influenza virus vaccine are administered concomitantly, revaccination should be considered when appropriate. The product labeling for zanamivir recommends waiting 24 hours after cessation of the drug before administration of live influenza virus vaccine.

References

"Product Information. Relenza (zanamivir)" Glaxo Wellcome, Research Triangle Pk, NC.
"Product Information. Xofluza (baloxavir marboxil)." Genentech, South San Francisco, CA.
"Product Information. FluMist (influenza virus vaccine, live, trivalent)." Medimmune Inc, Gaithersburg, MD.
"Product Information. Rapivab (peramivir)." BioCryst Pharmaceuticals Inc, Durham, NC.
"Product Information. Influenza Virus Vaccine, H1N1, Live (influenza virus vaccine, H1N1, live)." Medimmune Inc, Gaithersburg, MD.

FluMist Quadrivalent

Generic Name: influenza virus vaccine, live, trivalent

Brand name: FluMist Quadrivalent, FluMist 2018-2019, Flumist, FluMist 2010-2011, FluMist 2011-2012, FluMist 2012-2013, FluMist 2013-2014, FluMist 2014-2015, FluMist 2015-2016, FluMist 2016-2017, FluMist Quadrivalent 2019-2020

Synonyms: n.a.

What is FluMist Quadrivalent?

Virazole

Generic Name: ribavirin

Brand name: Virazole, Copegus, Ribasphere, Rebetol, RibaPak, RibaTab, RibaPak 600, Moderiba, Moderiba 800 Dose Pack, Moderiba 1200 Dose Pack, Moderiba 1000 Dose Pack, Moderiba 600 Dose Pack

Synonyms: n.a.

What is Virazole?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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