Fluocinolone and neomycin topical and Insulin glulisine
Determining the interaction of Fluocinolone and neomycin topical and Insulin glulisine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The efficacy of insulin and other antidiabetic agents may be diminished by topical corticosteroids, particularly during prolonged or indiscriminate use. Corticosteroids can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis. Systemic absorption of topical corticosteroids may occur depending on the vehicle and concentration of the preparation, the size of the application area, the integrity of the skin, and the duration of administration. Use of occlusive dressings over the applied areas may also increase percutaneous absorption. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios. If possible, the use of highly potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) should be avoided in children and limited to small areas for 2 weeks in adults. Close clinical monitoring of glycemic control is recommended if topical corticosteroids are administered chronically and/or to large areas in diabetic patients.
- "Product Information. Temovate (clobetasol)." Glaxo Wellcome, Research Triangle Park, NC.
- Ludvik B, Clodi M, Kautzky-Willer A, Capek M, Hartter E, Pacini G, Prager R "Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans." Diabetologia 36 (1993): 84-7
- Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
- "Product Information. Psorcon (diflorasone topical)." Rhone-Poulenc Rorer, Collegeville, PA.
- Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
- "Product Information. Ultravate (halobetasol)." Bristol-Myers Squibb, Princeton, NJ.
- Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
- "Product Information. Diprolene (betamethasone topical)." Schering Laboratories, Kenilworth, NJ.
Generic Name: fluocinolone / neomycin topical
Brand name: Neo-Synalar
Synonyms: Neomycin and Fluocinolone
Generic Name: insulin glulisine
Brand name: Apidra, Apidra OptiClik Cartridge, Apidra SoloStar Pen
Synonyms: Insulin Glulisine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fluocinolone and neomycin topical-Insulin Glulisine (Cartridges and Pens)
- Fluocinolone and neomycin topical-Insulin Glulisine (Vials)
- Fluocinolone and neomycin topical-Insulin glulisine Subcutaneous
- Fluocinolone and neomycin topical-Insulin human inhaled Inhalation
- Fluocinolone and neomycin topical-Insulin human regular Injection
- Fluocinolone and neomycin topical-Insulin inhalation
- Insulin glulisine-Fluocinolone Cream
- Insulin glulisine-Fluocinolone Cream and Ointment
- Insulin glulisine-Fluocinolone Intraocular
- Insulin glulisine-Fluocinolone Oil
- Insulin glulisine-Fluocinolone Oil (Body Oil)
- Insulin glulisine-Fluocinolone Oil (Scalp Oil)