Fluorouracil injection and Vincasar PFS
Determining the interaction of Fluorouracil injection and Vincasar PFS and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration of fluorouracil and vincristine may lead to an earlier onset and/or increased severity of side effects. The mechanism is inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If fluorouracil and vincristine are used concomitantly, caution and close observation are advised.
- Zhou-Pan XR, Seree E, Zhou XJ, et al "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res 53 (1993): 5121-6
- "Product Information. Oncovin (vincristine)." Lilly, Eli and Company, Indianapolis, IN.
Generic Name: fluorouracil
Brand name: Adrucil
Synonyms: Fluorouracil (injection), Fluorouracil (Systemic)
Generic Name: vincristine
Brand name: Oncovin, Vincasar PFS
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fluorouracil injection-Vincristine
- Fluorouracil injection-Vincristine (Liposomal)
- Fluorouracil injection-Vincristine Intravenous
- Fluorouracil injection-Vincristine liposome
- Fluorouracil injection-Vincristine liposome Intravenous
- Fluorouracil injection-Vincristine Sulfate
- Vincasar PFS-Fluorouracil Intravenous, Injection
- Vincasar PFS-Fluovix
- Vincasar PFS-Fluoxetine
- Vincasar PFS-Fluoxetine and olanzapine
- Vincasar PFS-Fluoxetine Capsules
- Vincasar PFS-Fluoxetine Capsules and Tablets