Fluorouracil Intravenous, Injection and Sorafenib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using fluorouracil together with SORAfenib may increase the effects of fluorouracil. Contact your doctor if your condition changes or if you experience extreme fatigue, easy bruising or bleeding, black, bloody or tarry stools, fever, chills, sores in the mouth or throat, severe vomiting or diarrhea. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with sorafenib may alter the plasma concentrations of fluorouracil. Both increases (21% to 47%) and decreases (10%) in fluorouracil systemic exposure (AUC) have been observed. The mechanism of interaction has not been described.

MANAGEMENT: Caution is advised if fluorouracil is prescribed in combination with sorafenib. Patients should be monitored closely for altered efficacy or potential toxicities of fluorouracil such as leukopenia, thrombocytopenia, stomatitis, esophagopharyngitis, gastrointestinal ulceration or bleeding, and diarrhea.

Fluorouracil Intravenous, Injection

Generic Name: fluorouracil

Brand name: Adrucil

Synonyms: Fluorouracil (injection), Fluorouracil (Systemic)

What is Fluorouracil Intravenous, Injection?

Sorafenib

Generic Name: sorafenib

Brand name: Nexavar

Synonyms: SORAfenib

What is Sorafenib?