Fluoxetine Solution and Lopinavir and Ritonavir Solution
Determining the interaction of Fluoxetine Solution and Lopinavir and Ritonavir Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using FLUoxetine together with ritonavir may alter the effects of both medications. Contact your doctor if you experience nausea, vomiting, fever, sleepiness, rapid or uneven heartbeat, confusion, fainting, or if your condition worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Fluoxetine may raise the plasma concentration of ritonavir by inhibiting its metabolism. A 19% increase has been observed in the mean area under the plasma concentration-time curve of ritonavir. One pharmacokinetic study concluded that no ritonavir dose adjustment was necessary. Also, ritonavir appears to be a moderately competitive inhibitor of the enzyme CYP450 2D6. Elevated serum fluoxetine levels are therefore possible.
MANAGEMENT: If fluoxetine and ritonavir must be used concurrently, the patient should be monitored for fluoxetine toxicity (nausea, vomiting, dizziness, confusion, vertigo, tremor, and gait abnormalities). A reduction in fluoxetine dosage may be necessary.
- "Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
- Ouellet D, Hsu A, Qian J, Lamm JE, Cavanaugh JH, Leonard JM, Granneman GR "Effect of fluoxetine on pharmacokinetics of ritonavir." Antimicrob Agents Chemother 42 (1998): 3107-12
Generic Name: fluoxetine
Brand name: Prozac, Prozac Weekly, PROzac Pulvules, Sarafem, Rapiflux, Selfemra
Synonyms: Fluoxetine, FLUoxetine
Generic Name: lopinavir / ritonavir
Brand name: Kaletra
Synonyms: Lopinavir and ritonavir, Lopinavir and Ritonavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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