Fluphenazine hydrochloride and Methylnaltrexone

• Generic Name: fluphenazine
• Dosage Forms: n.a.
• Other Brand Names: Permitil, Prolixin, Prolixin Decanoate, Prolixin Enanthate

Symptomatic management of psychotic disorders (i.e., schizophrenia).

The long-acting decanoate ester is used mainly for maintenance therapy in patients with chronic schizophrenic disorder who cannot be relied on to take oral antipsychotic drugs; do not use for acute management of severely agitated patients.

Efficacy not established for management of behavioral complications in mental retardation.

• Generic Name: methylnaltrexone
• Dosage Forms: n.a.
• Other Brand Names: Relistor

Methylnaltrexone blocks the effects of opioid medication. An opioid is sometimes called a narcotic.

Methylnaltrexone reduces constipation caused by using narcotic medicine for 4 weeks or longer. Methylnaltrexone works by preventing constipation without reducing the pain-relieving effects of the narcotic.

Methylnaltrexone is given to adults who use narcotic medicine to treat severe chronic pain that is not caused by cancer. Methylnaltrexone injection is also for use in adults who have advanced illness and are receiving palliative care (treatment to relieve suffering and improve quality of life during a serious illness).

Methylnaltrexone is usually given after laxatives have been tried without successful treatment of constipation.

Methylnaltrexone may also be used for purposes not listed in this medication guide.