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Fluphenazine Hydrochloride Injection and Lithium

Determining the interaction of Fluphenazine Hydrochloride Injection and Lithium and the possibility of their joint administration.

Check result:

Fluphenazine Hydrochloride Injection <> Lithium

Relevance: 05.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking lithium tell your doctor if you also use fluPHENAZine. You may need dose adjustments or special tests in order to safely take both medications together. Contact your doctor if you have changes in behavior, seizures, or fever. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Although lithium and phenothiazines are frequently used together in the setting of acute mania, concurrent administration may induce a number of neurologic and psychiatric effects (despite decreased phenothiazine levels during lithium therapy). Mental status changes, delirium, seizures, extrapyramidal effects, fever, and other symptoms have been reported. The mechanism is unknown.

MANAGEMENT: Patients receiving lithium and a phenothiazine should be closely monitored for altered efficacy and safety. In some circumstances, discontinuation of one or both agents may be necessary.

References

Rivera-Calimlim L, Kerzner B, Karch FE "Effect of lithium on plasma chlorpromazine levels." Clin Pharmacol Ther 23 (1978): 451-5
Sachdev PS "Lithium potentiation of neuroleptic-related extrapyramidal side effects." Am J Psychiatry 143 (1986): 942
"Product Information. Eskalith (lithium)." SmithKline Beecham, Philadelphia, PA.
Prakash R, Kelwala S, Ban TA "Neurotoxicity with combined administration of lithium and a neuroleptic." Compr Psychiatry 23 (1982): 567-71
Stevenson R, Blanshard C, Patterson D "Ventricular fibrillation due to lithium withdrawal: an interaction with chlorpromazine?" Postgrad Med J 65 (1989): 936-8
Yassa R "A case of lithium-chlorpromazine interaction." J Clin Psychiatry 47 (1986): 90-1
Singh SV "Lithium carbonate/fluphenazine decanoate producing irreversible brain damage." Lancet 2 (1982): 278

Fluphenazine Hydrochloride Injection

Generic Name: fluphenazine

Brand name: Permitil, Prolixin, Prolixin Decanoate, Prolixin Enanthate

Synonyms: Fluphenazine, FluPHENAZine

What is Fluphenazine Hydrochloride Injection?

Lithium

Generic Name: lithium

Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: n.a.

What is Lithium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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