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Fluphenazine Hydrochloride Injection and Phenytoin Extended-Release Capsules

Determining the interaction of Fluphenazine Hydrochloride Injection and Phenytoin Extended-Release Capsules and the possibility of their joint administration.

Check result:

Fluphenazine Hydrochloride Injection <> Phenytoin Extended-Release Capsules

Relevance: 05.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking phenytoin, tell your doctor if you also use fluPHENAZine. You may need dose adjustments or special tests in order to safely take both medications together. You should notify your doctor if you have symptoms of drowsiness, visual disturbances, change in mental status, seizures, and nausea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Concurrent use of phenothiazines and phenytoin may increase the effect of phenytoin and decrease the effect of the phenothiazine. The mechanism is unknown and clinical data have been inconsistent.

MANAGEMENT: Close monitoring for clinical and laboratory evidence of phenytoin toxicity is indicated. Patients should be advised to notify their physician if they experience symptoms of possible hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.

References

Vincent FM "Phenothiazine-induced phenytoin intoxication." Ann Intern Med 93 (1980): 56-7
Linnoila M, Viukari M, Vaisanen K, Auvinen J "Effect of anticonvulsants on plasma haloperidol and thioridazine levels." Am J Psychiatry 137 (1980): 819-21
Haidukewych D, Rodin EA "Effect of phenothiazines on serum antiepileptic drug concentrations in psychiatric patients with seizure disorder." Ther Drug Monit 7 (1985): 401-4
Houghton GW, Richens A "Inhibition of phenytoin metabolism by other drugs used in epilepsy." Int J Clin Pharmacol 12 (1975): 210-6
Sands CD, Robinson JD, Salem RB, Stewart RB, Muniz C "Effect of thioridazine on phenytoin serum concentration: a retrospective study." Drug Intell Clin Pharm 21 (1987): 267-72

Fluphenazine Hydrochloride Injection

Generic Name: fluphenazine

Brand name: Permitil, Prolixin, Prolixin Decanoate, Prolixin Enanthate

Synonyms: Fluphenazine, FluPHENAZine

What is Fluphenazine Hydrochloride Injection?

Phenytoin Extended-Release Capsules

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin Extended-Release Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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