Flurazepam Hydrochloride and Ortho Evra
Determining the interaction of Flurazepam Hydrochloride and Ortho Evra and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Oral contraceptives may prolong the half-life of certain benzodiazepines that undergo hepatic oxidative metabolism (such as diazepam and chlordiazepoxide). Other benzodiazepines also may participate in this interaction. Close observation for signs and symptoms of altered benzodiazepine effect is recommended.
- Stoehr GP, Kroboth PD, Juhl RP, Wender DB, Phillips JP, Smith RB "Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics." Clin Pharmacol Ther 36 (1984): 683-90
- Abernethy DR, Greenblatt DJ, Divoll M, Arendt R, Ochs HR, Shader RI "Impairment of diazepam metabolism by low-dose estrogen-containing oral-contraceptive steroids." N Engl J Med 306 (1982): 791-2
- Patwardhan RV, Mitchell MC, Johnson RF, Schenker S "Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines." Hepatology 3 (1983): 248-53
- Scavone JM, Greenblatt DJ, Locniskar A, Shader RI "Alprazolam pharmacokinetics in women on low-dose oral contraceptives." J Clin Pharmacol 28 (1988): 454-7
Generic Name: flurazepam
Brand name: Dalmane
Synonyms: Flurazepam
Generic Name: ethinyl estradiol / norelgestromin
Brand name: Ortho Evra, Xulane
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Flurazepam Hydrochloride-Ortho Micronor
- Flurazepam Hydrochloride-Ortho Micronor Oral
- Flurazepam Hydrochloride-Ortho Tri-Cyclen
- Flurazepam Hydrochloride-Ortho Tri-Cyclen (28)
- Flurazepam Hydrochloride-Ortho Tri-Cyclen Lo
- Flurazepam Hydrochloride-Ortho-Cept
- Ortho Evra-Flurbiprofen
- Ortho Evra-Flurbiprofen (Systemic)
- Ortho Evra-Flurbiprofen ophthalmic
- Ortho Evra-Flurbiprofen Ophthalmic Solution
- Ortho Evra-Flurbiprofen Sodium eent
- Ortho Evra-Flurbiprofen Tablets