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Flutabs and Valdecoxib

Determining the interaction of Flutabs and Valdecoxib and the possibility of their joint administration.

Check result:

Flutabs <> Valdecoxib

Relevance: 23.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

According to the manufacturer, the coadministration with valdecoxib 40 mg twice a day for 7 days has been shown to significantly increase the plasma concentrations of dextromethorphan. The proposed mechanism is decreased clearance of dextromethorphan due to inhibition of the CYP450 2D6 enzymatic pathway by valdecoxib at high dosages. However, the dextromethorphan levels reported were still almost 5-fold lower than those observed in CYP450 2D6 poor metabolizers. No particular intervention should be necessary when valdecoxib is administered under normal circumstances with dextromethorphan. At unusually high dosages of valdecoxib, there may be a theoretical risk of increased adverse effects of dextromethorphan such as drowsiness, dizziness, excitation, mental confusion, and respiratory depression. Parecoxib, a prodrug of valdecoxib, may also interact.

References

"Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.

Flutabs

Generic Name: acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine

Brand name: Duraflu, Robitussin Cold Cough and Flu, Theraflu Max-D Severe Cold & Flu, Sudafed Cold and Cough Liquicaps, Theraflu Chest and Cough, Tylenol Cold Severe Congestion Non-Drowsy, Sudafed Sinus and Cold Liquicaps, Phlemgesic, Maxiflu DM, Flutabs, Tylenol Cold Severe Congestion

Synonyms: n.a.

What is Flutabs?

Valdecoxib

Generic Name: valdecoxib

Brand name:

Synonyms: Valdecoxib (Oral)

What is Valdecoxib?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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