Fluticasone, umeclidinium, and vilanterol Inhalation and Hydrocortisone Rectal Foam
Determining the interaction of Fluticasone, umeclidinium, and vilanterol Inhalation and Hydrocortisone Rectal Foam and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Although they are often combined in clinical practice, the concomitant use of beta-2 adrenergic agonists and corticosteroids may result in additive hypokalemic effects. Since beta-2 agonists can sometimes cause QT interval prolongation, the development of hypokalemia may potentiate the risk of ventricular arrhythmias including torsade de pointes. However, clinical data are limited, and the potential significance is unknown. Patients who are receiving systemic or nebulized formulations of beta-2 agonists, high dosages of inhaled beta-2 agonists, or systemic corticosteroid therapy may be at a greater risk of developing hypokalemia.
- "Product Information. Foradil (formoterol)" Novartis Pharmaceuticals, East Hanover, NJ.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Generic Name: fluticasone / umeclidinium / vilanterol
Brand name: Trelegy Ellipta
Synonyms: Fluticasone, umeclidinium, and vilanterol, Umeclidinium, and Vilanterol
Generic Name: hydrocortisone
Brand name: Cortef, Colocort, Cortenema, Cortifoam, Solu-Cortef
Synonyms: Hydrocortisone, Hydrocortisone (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fluticasone, umeclidinium, and vilanterol Inhalation-Hydrocortisone rectal foam, enema
- Fluticasone, umeclidinium, and vilanterol Inhalation-Hydrocortisone Rectal Suppositories
- Fluticasone, umeclidinium, and vilanterol Inhalation-Hydrocortisone Rectal Suspension
- Fluticasone, umeclidinium, and vilanterol Inhalation-Hydrocortisone Sodium Phosphate
- Fluticasone, umeclidinium, and vilanterol Inhalation-Hydrocortisone Sodium Succinate
- Fluticasone, umeclidinium, and vilanterol Inhalation-Hydrocortisone Suppository
- Hydrocortisone Rectal Foam-Flutone
- Hydrocortisone Rectal Foam-FluTuss XP Oral
- Hydrocortisone Rectal Foam-Fluvastatin
- Hydrocortisone Rectal Foam-Fluvastatin Capsules
- Hydrocortisone Rectal Foam-Fluvastatin ER Tablets
- Hydrocortisone Rectal Foam-Fluvastatin Extended-Release Tablets