Fluvastatin ER Tablets and Nicotinex
Determining the interaction of Fluvastatin ER Tablets and Nicotinex and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using fluvastatin together with niacin may cause a dangerous side effect on your muscles. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. You should also watch for muscle symptoms and call the doctor if you have muscle pain, tenderness, or weakness, especially if you also have dark colored urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Severe myopathy and rhabdomyolysis have been reported with concomitant use of lovastatin and niacin, and may be possible with other HMG-CoA inhibitors such as fluvastatin. The mechanism is unknown.
MANAGEMENT: Patients should be instructed to report symptoms of muscular pain, weakness, or tenderness. If such symptoms occur, creatine kinase should be measured. Fluvastatin and niacin should be discontinued if creatine kinase is elevated or if myopathy is suspected.
- Deslypere JP "Clinical implications of the biopharmaceutical properties of fluvastatin." Am J Cardiol 73 (1994): d12-7
- Smith HT, Jokubaitis LA, Troendle AJ, Hwang DS, Robinson WT "Pharmacokinetics of fluvastatin and specific drug interactions." Am J Hypertens 6 (1993): s375-82
- Jacobson TA, Chin MM, Fromell GJ, Jokubaitis LA, Amorosa LF "Fluvastatin with and without niacin for hypercholesterolemia." Am J Cardiol 74 (1994): 149-54
- Malloy MJ, Kane JP, Kunitake ST, Tun P "Complementarity of colestipol, niacin, and lovastatin in treatment of severe familial hypercholesterolemia." Ann Intern Med 107 (1987): 616-23
- Jacobson TA, Amorosa LF "Combination therapy with fluvastatin and niacin in hypercholesterolemia: a preliminary report on safety." Am J Cardiol 73 (1994): d25-9
- "Product Information. Lescol (fluvastatin)." Novartis Pharmaceuticals, East Hanover, NJ.
- Reaven P, Witztum JL "Lovastatin, nicotinic acid, and rhabdomyolysis." Ann Intern Med 109 (1988): 597-8
Generic Name: fluvastatin
Brand name: Lescol, Lescol XL
Synonyms: Fluvastatin
Generic Name: niacin
Brand name: B-3-50, B3-500-Gr, Niacin SR, Niacor, Niaspan ER, Slo-Niacin
Synonyms: Nicotinex (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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