Fluvastatin ER Tablets and Rifadin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using rifAMPin together with fluvastatin may decrease the effects of fluvastatin. Contact your doctor if your condition changes or if your cholesterol increases. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with rifampin may decrease the plasma concentrations of fluvastatin due to induction of its metabolism via CYP450 2C9. Plasma clearance of immediate-release fluvastatin has been reported to increase by 95% during rifampin coadministration, resulting in a 59% decrease in peak plasma concentration (Cmax) and a 51% decrease in area under the plasma concentration-time curve (AUC) of fluvastatin.

MANAGEMENT: Use of fluvastatin in combination with rifampin may result in diminished hypolipidemic efficacy, and dosage adjustment of the statin may be necessary during long-term treatment with rifampin. Alternatively, pravastatin may be a suitable substitution, as it is not a substrate of CYP450 enzymes or P-glycoprotein. One study reported only a 31% decrease in the mean AUC of single-dose pravastatin following pretreatment with rifampin, and the interaction did not occur in all subjects.

Fluvastatin ER Tablets

Generic Name: fluvastatin

Brand name: Lescol, Lescol XL

Synonyms: Fluvastatin

What is Fluvastatin ER Tablets?

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?